<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">We haven’t explored this. On re-assembly projects I rarely find more than a handful of instances where a gene was obviously split across contigs in the first assembly's annotation. More often what I find is that extra contigs tend to contain fragments of a gene that is complete on another contig in the same assembly (caused by high heterozygosity, so maternal and paternal contigs can assemble independently).<div class=""><br class=""></div><div class="">—Carson</div><div class=""><br class=""><div class=""><div><br class=""><blockquote type="cite" class=""><div class="">On Oct 23, 2020, at 12:15 AM, Emmanuel Nnadi <<a href="mailto:eennadi@gmail.com" class="">eennadi@gmail.com</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div dir="ltr" class="">Hi Carson,<div class="">Greetings! This is just a random question that came to my mind. Looking at the way maker structures files and brings contigs together based on "gene" locations. Can this be explored to improve genome assemblies? Maybe a tool that can work from a good annotation to generating a set of improved genome assembly based on these gene locations</div><div class=""><br class=""></div><div class=""><br class=""></div><div class="">Just a thought<br clear="all" class=""><div class=""><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr" class=""><div class=""><div dir="ltr" class="">Nnaemeka Emmanuel Nnadi,Ph.D<div class="">Department of Microbiology,</div><div class="">Faculty of Natural and Applied Science,</div><div class="">Plateau State University, Bokkos, Plateau State, Nigeria.</div><div class="">+2348068124819</div><div class="">Publications: </div><div class=""> <a href="https://www.researchgate.net/profile/Emmanuel_Nnadi/publications" target="_blank" class="">https://www.researchgate.net/profile/Emmanuel_Nnadi/publications</a></div></div></div></div></div></div></div></div>
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