[maker-devel] maker-2.23

Carson Holt carsonhh at gmail.com
Fri Feb 24 08:49:46 MST 2012


I'm glad it is working now.  There is nothing harder than tracking down
errors in Perl that are really coming from a C compiled source outside of
Perl (malloc, folding_constents, etc.).

Thanks,
Carson



From:  Rodolfo Aramayo <raramayo at tamu.edu>
Date:  Fri, 24 Feb 2012 09:43:08 -0600
To:  Carson Holt <carsonhh at gmail.com>
Cc:  MAKER <maker-devel at yandell-lab.org>
Subject:  Re: [maker-devel] maker-2.23

Thanks Carson,

So I did the following:

Deleted the Maker installation
Re-configure, re-compiled and re-installed mpich2
Re-installed CPAN and all the CPAN-modules required by Maker
Re-compiled and re-installed Maker
Re-installed Genemark
 and now things work!

The question remains, why did this failed?
The only thing I can think of, the only thing I noticed, is the fact that
forks::shared and threads::shared were installed by CPAN as if they had not
been installed before??
But they were...so..perhaps CPAN modules got broken during a major MacPorts
upgrade I did over the weekend, where many, many MacPorts perl modules were
upgraded

Like they say: No Good Deed Shall Go Unpunished!

It is like I had to pay the Gods their tribute in pain over the fact that I
dared to upgrade the software

Thanks for your help

--Rodolfo



On Thu, Feb 23, 2012 at 11:08, Carson Holt <carsonhh at gmail.com> wrote:
> Does it indicate at any level what the compilation error is?
> 
> Could you pack up your job and send it to me?  I'll just try it on a couple of
> system types.  A malloc error with perl would normally happen at the C level,
> so it's a matter of identifying what module is being called.
> 
> Thanks,
> Carson
> 
> From:  Rodolfo Aramayo <raramayo at tamu.edu>
> Date:  Thu, 23 Feb 2012 11:00:37 -0600
> 
> To:  Carson Holt <carsonhh at gmail.com>
> Cc:  MAKER <maker-devel at yandell-lab.org>
> Subject:  Re: [maker-devel] maker-2.23
> 
> Carson,
> 
> Reinstalled storable, forks and forks::shared
> Re-compiled maker
> Same problem
> 
> Change from forks/forks::shared to threads/threads::shared in the compiled
> executable and
> Running maker gives me:
> 
> "Execution of /usr/local/bioinfosoft/maker-2.23/bin/maker aborted due to
> compilation errors."
> 
> Ideas?
> 
> Thanks
> 
> --R
> 
> 
> 
> 
> 
> On Thu, Feb 23, 2012 at 09:26, Carson Holt <carsonhh at gmail.com> wrote:
>> All MAKER versions after 2.2 use the CPAN forks.pm <http://forks.pm>  module
>> rather than threads.pm <http://threads.pm> .  forks.pm <http://forks.pm>  is
>> just a drop in replacement for threads.pm <http://threads.pm>  so you can use
>> the same syntax for forks as you do with threads.  Even if you have perl
>> compiled with threads MAKER still uses forks.pm <http://forks.pm>  (I am
>> referring to the about the module forks.pm <http://forks.pm>  and not forks
>> themselves).  The place where you get the error suggests the problem is at
>> the C level, so the forks.pm <http://forks.pm>  module from CPAN and
>> Storable.pm are the  two most likely culprits.  Reinstalling both of those
>> would be the first thing to do.  If you have threaded perl you can just
>> change the 'use' statement at the start of MAKER, but if you don't have
>> threaded perl, just reinstall forks.pm <http://forks.pm> .  Don't worry about
>> changing the perl installation.
>> 
>> Thanks,
>> Carson
>> 
>> From:  Rodolfo Aramayo <raramayo at tamu.edu>
>> Date:  Thu, 23 Feb 2012 09:17:36 -0600
>> To:  Carson Holt <carsonhh at gmail.com>
>> Cc:  MAKER <maker-devel at yandell-lab.org>
>> Subject:  Re: [maker-devel] maker-2.23
>> 
>> Thanks Carson...please see below
>> 
>> On Thu, Feb 23, 2012 at 08:56, Carson Holt <carsonhh at gmail.com> wrote:
>>> Try two things for me.  Install/Re-install the latest version of the CPAN
>>> Storable module.  Install/Re-install forks and forks::shared from CPAN.
>>> Alternatively change 'use forks' to 'use threads' and 'use forks::shared' to
>>> 'use threads::shared' in the MAKER executable.  Those modules are supposed
>>> to be drop in replacements for each other.
>> 
>> which modules? I assume threads will be dropped, right?
>> and if this is the case what are the advantages/disadvantages of using Perl
>> 5, version 12, subversion 3 (v5.12.3) built for darwin-thread-multi-2level
>> should I change to non-threads version?? or it does not matter
>> 
>> Thanks
>> 
>> --R
>> 
>>> 
>>> Thanks,
>>> Carson
>>> 
>>> From:  Rodolfo Aramayo <raramayo at tamu.edu>
>>> Date:  Thu, 23 Feb 2012 08:47:32 -0600
>>> To:  MAKER <maker-devel at yandell-lab.org>
>>> Subject:  [maker-devel] maker-2.23
>>> 
>>> I am running into an unusual problem
>>> If I run Maker in the maker01 directory, say "/Volumes/g0006/maker/maker01"
>>> things go well no problem so far...but if I start a second maker inside the
>>> maker02 directory:  "/Volumes/g0006/maker/maker02"
>>> the second maker quits with a: "[3]+  Abort trap              nohup maker"
>>> and in the nohup file I see the following:
>>> 
>>> ############################################################################
>>> ##############################
>>> ...
>>> ...
>>> ...
>>> ...
>>> #-------------------------------#
>>> re reading genemark report.
>>> /Volumes/a0005/02SK4_01assembly_total_final_1000-10000/SK4_01assembly_total_
>>> final_1000-10000.maker.output/SK4_01assembly_total_final_1000-10000_datastor
>>> e/C6/70/NODE_2_length_2929_cov_50.101059//theVoid.NODE_2_length_2929_cov_50.
>>> 101059/NODE_2_length_2929_cov_50%2E101059.all.Ralstonia_solanacearum%2Emod.g
>>> enemark
>>> running  genemark.
>>> #--------- command -------------#
>>> Widget::genemark:
>>> /opt/local/bin/perl
>>> /usr/local/bioinfosoft/maker-2.23/bin/../lib/Widget/genemark/gmhmm_wrap -m
>>> /Volumes/a0003/bioinfodata/genemark/hmm/Ralstonia_solanacearum_plasmid_pGMI1
>>> 000MP.mod -g /usr/local/bioinfosoft/genemark/gmhmmp -p
>>> /usr/local/bioinfosoft/genemark/probuild -o
>>> /Volumes/a0005/02SK4_01assembly_total_final_1000-10000/SK4_01assembly_total_
>>> final_1000-10000.maker.output/SK4_01assembly_total_final_1000-10000_datastor
>>> e/C6/70/NODE_2_length_2929_cov_50.101059//theVoid.NODE_2_length_2929_cov_50.
>>> 101059/NODE_2_length_2929_cov_50%2E101059.all.Ralstonia_solanacearum_plasmid
>>> _pGMI1000MP%2Emod.genemark
>>> /Volumes/a0005/02SK4_01assembly_total_final_1000-10000/SK4_01assembly_total_
>>> final_1000-10000.maker.output/SK4_01assembly_total_final_1000-10000_datastor
>>> e/C6/70/NODE_2_length_2929_cov_50.101059//theVoid.NODE_2_length_2929_cov_50.
>>> 101059/query.fasta
>>> #-------------------------------#
>>> formating database...
>>> #--------- command -------------#
>>> Widget::formater:
>>> /usr/local/bin/makeblastdb -dbtype prot -in
>>> /tmp/maker_hZ_8Uc/uniprot_sprot%2Efasta.mpi.10.0
>>> #-------------------------------#
>>> running  blast search.
>>> #--------- command -------------#
>>> Widget::blastx:
>>> /usr/local/bin/blastx -db /tmp/maker_hZ_8Uc/uniprot_sprot%2Efasta.mpi.10.0
>>> -query /tmp/maker_hZ_8Uc/rank0/NODE_2_length_2929_cov_50%2E101059.0
>>> -num_alignments 10000 -num_descriptions 10000 -evalue 1e-06 -dbsize 300
>>> -searchsp 20000000 -num_threads 7 -seg yes -soft_masking true -lcase_masking
>>> -show_gis -out 
>>> /Volumes/a0005/02SK4_01assembly_total_final_1000-10000/SK4_01assembly_total_
>>> final_1000-10000.maker.output/SK4_01assembly_total_final_1000-10000_datastor
>>> e/C6/70/NODE_2_length_2929_cov_50.101059//theVoid.NODE_2_length_2929_cov_50.
>>> 101059/NODE_2_length_2929_cov_50%2E101059.0.uniprot_sprot%2Efasta.blastx.tem
>>> p_dir/uniprot_sprot%2Efasta.mpi.10.0.blastx
>>> #-------------------------------#
>>> deleted:97 hits
>>> perl(12478) malloc: *** error for object 0x1033bada0: pointer being freed
>>> was not allocated
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> perl(12478) malloc: *** error for object 0x1033b9c18: incorrect checksum for
>>> freed object - object was probably modified after being freed.
>>> *** set a breakpoint in malloc_error_break to debug
>>> 
>>> ############################################################################
>>> ##############################
>>> 
>>> I am using Maker 2.23
>>> 
>>> I see this problem in Maker with and without mpich2 compilation
>>> I am using:
>>> 
>>> Perl 5, version 12, subversion 3 (v5.12.3) built for
>>> darwin-thread-multi-2level
>>> 
>>> 
>>> Any ideas?
>>> 
>>> Thanks
>>> _______________________________________________ maker-devel mailing list
>>> maker-devel at box290.bluehost.comhttp://box290.bluehost.com/mailman/listinfo/m
>>> aker-devel_yandell-lab.org
>> 
> 



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